Drug Transport in the Vitreous
Overview
We are developing a 3-D kinetic model to determine how exosomes overcome barriers to transport, particularly, (1) factors determining rate of diffusion across the vitreous into the retina, (2) distance of penetration into the retina, (3) dynamic concentration distribution in the vitreous, (4) retinal barriers to penetration, (5) design factors for exosomes surface composition to rapidly cross into retina, and (6) design factors to target specific retinal cells.
Figure 1. For retina regeneration in intravitreal injection, exosomes have to migrate from the point of injection to retina and penetrate into subsequent layers.